Full Description
Identifies villin, an actin-binding protein present in human renal epithelial cells, used as a marker for gastrointestinal tract–derived carcinomas. Along with CDX2, villin is a highly specific and moderately sensitive marker for colorectal and other GI tract (pancreatobiliary) carcinomas, typically showing a brush border pattern. A subset of lung adenocarcinomas may also express villin.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1