IHC

TTF-1

Identifies a nuclear transcription factor primarily expressed in lung and thyroid neoplasms. It is present in most lung carcinomas (non-neuroendocrine and endocrine) and nearly all thyroid carcinomas except anaplastic types. This marker is useful in distinguishing primary from metastatic carcinomas, particularly in the lung.

Synonyms

Thyroid Transcription Factor-1

Full Description

Identifies a nuclear transcription factor primarily expressed in lung and thyroid neoplasms. It is present in most lung carcinomas (non-neuroendocrine and endocrine) and nearly all thyroid carcinomas except anaplastic types. This marker is useful in distinguishing primary from metastatic carcinomas, particularly in the lung.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1