Molecular

TP53 Mutation Analysis

Bi-directional sequencing analysis of TP53 gene in exons 4-9. TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. It aids in prognosis and/or therapy selection in patients with chronic lymphocytic leukemia (CLL) and germline mutations in TP53 are the cause of Li-Fraumeni Syndrome.

Full Description

Bi-directional sequencing analysis of TP53 gene in exons 4-9. TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. It aids in prognosis and/or therapy selection in patients with chronic lymphocytic leukemia (CLL) and germline mutations in TP53 are the cause of Li-Fraumeni Syndrome.

Methodology

Molecular

Specimen Requirements

Whole blood (3-5 mL), Bone marrow (1-2 mL), in Lavender-top (EDTA) tube. Formalin-fixed,paraffin-embedded (FFPE) tissue block (preferred) or slides (1 H&E slide,plus 5-10 unstained slides cut at 5+ microns). Please use positively charged slides and 10% NBF fixative. Do not use zinc fixatives.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen. Do not freeze.

Turnaround Time

7 days

CPT Codes

81352