IHC

TLE-1

Identifies a transducing-like enhancer (TLE) protein, expressed in immature epithelial cells undergoing differentiation. This antibody is a highly specific marker for synovial sarcoma and helps distinguish it from other sarcomas, including histologically similar tumors like malignant peripheral nerve sheath tumor.

Synonyms

Transducin-Like Enhancer Protein 1

Full Description

Identifies a transducing-like enhancer (TLE) protein, expressed in immature epithelial cells undergoing differentiation. This antibody is a highly specific marker for synovial sarcoma and helps distinguish it from other sarcomas, including histologically similar tumors like malignant peripheral nerve sheath tumor.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1