IHC

TIA-1

Identifies a cytoplasmic protein with a coarse granular pattern found in cytotoxic T cells and NK cells, as well as neoplasms derived from these lineages, including most anaplastic large cell lymphomas. It also labels granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, and pulmonary angiocentric lymphomas of T or NK phenotype. B-cell lymphomas, Hodgkin lymphoma, and lymphoblastic leukemias are negative.