IHC

Thyroglobulin (TGB)

Identifies thyroglobulin, a dimeric protein produced by the thyroid gland. It is useful for confirming metastatic papillary and follicular thyroid carcinomas, though combining thyroglobulin staining with TTF-1 and PAX-8 expression is generally more reliable due to occasional nonspecific staining.

Synonyms

TG

Full Description

Identifies thyroglobulin, a dimeric protein produced by the thyroid gland. It is useful for confirming metastatic papillary and follicular thyroid carcinomas, though combining thyroglobulin staining with TTF-1 and PAX-8 expression is generally more reliable due to occasional nonspecific staining.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1