Full Description
Identifies a transcription factor expressed in almost all cases of mantle cell lymphoma (MCL) including cyclin D1-negative MCL. Routine use of anti-SOX11 in cases of suspected CD5+ diffuse large B cell lymphoma might help identify additional cases of cyclin D1-negative blastoid MCL. It is not expressed in potential MCL mimics such as atypical chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, and marginal zone lymphoma.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
1 day: tech only. 2 days: with interpretation. 4 days: with consult report.
CPT Codes
88342 (or 88341 if not the first single antibody per specimen)