Full Description
Identifies SOX10, a highly specific and sensitive nuclear transcription factor expressed in nerve sheath tumors and melanomas, including conventional, spindle, and desmoplastic types. It is also seen in salivary gland and soft tissue tumors with myoepithelial differentiation, and is diffusely expressed in schwannoma, neurofibroma, and granular cell tumors. SOX10 is more specific than S100 and rarely expressed in other mesenchymal or epithelial tumors.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1