Full Description
Identifies SOX10, a nuclear transcription factor expressed in nerve sheath tumors and melanomas, including conventional, spindle, and desmoplastic subtypes. Also seen in myoepithelial tumors of salivary gland and soft tissue, and diffusely in schwannoma, neurofibroma, and granular cell tumors. More specific than S100.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1