IHC

Smoothelin

Identifies smoothelin, a cytoskeletal protein specific to smooth muscle cells. It helps distinguish true smooth muscle from cells with smooth muscle-like features, such as myofibroblasts, myoepithelial cells, and skeletal or cardiac muscle, and can differentiate muscularis propria from muscularis mucosa.

Full Description

Identifies smoothelin, a cytoskeletal protein specific to smooth muscle cells. It helps distinguish true smooth muscle from cells with smooth muscle-like features, such as myofibroblasts, myoepithelial cells, and skeletal or cardiac muscle, and can differentiate muscularis propria from muscularis mucosa.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1