IHC

Smooth Muscle Myosin (SMM)

Identifies a component of smooth muscle myosin, a protein expressed in cells and tumors showing smooth muscle or myoepithelial differentiation. This antibody reacts with human visceral and vascular smooth muscle cells and myoepithelial cells and is useful in distinguishing between benign sclerosing breast leasons and infiltrating carcinomas because it strongly stains the myoepithelial layer in the benign lesions while being negative in the infiltrating carcinomas.

Synonyms

SMMHC

Full Description

Identifies a component of smooth muscle myosin, a protein expressed in cells and tumors showing smooth muscle or myoepithelial differentiation. This antibody reacts with human visceral and vascular smooth muscle cells and myoepithelial cells and is useful in distinguishing between benign sclerosing breast leasons and infiltrating carcinomas because it strongly stains the myoepithelial layer in the benign lesions while being negative in the infiltrating carcinomas.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1