Full Description
SF1 is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli and Leydig cells, ovarian theca cells, hypothalamus, and anterior pituitary. Nuclear SF1 staining helps distinguish sex cord-stromal tumors (SCST) from non-sex cord-stromal tumors and is a valuable marker for determining adrenocortical origin. It is best used as part of a panel with other SCST markers, such as inhibin and calretinin.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1