Full Description
Identifies the succinate dehydrogenase complex subunit B (SDHB), a mitochondrial protein. Loss of SDHB expression by IHC indicates a mutation in any SDH subunit (SDHA, SDHB, SDHC, or SDHD) and is used in the evaluation of paragangliomas, pheochromocytomas, and gastrointestinal stromal tumors (GISTs) associated with SDH deficiency.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1