IHC

RB1 Retinoblastoma

Identifies the RB tumor suppressor protein, a key negative regulator of the cell cycle. Loss of RB function leads to uncontrolled cell proliferation. RB abnormalities are seen in a wide range of cancers, including breast, colon, prostate, kidney, nasopharyngeal tumors, and leukemias.

Synonyms

Retinoblastoma Protein

Full Description

Identifies the RB tumor suppressor protein, a key negative regulator of the cell cycle. Loss of RB function leads to uncontrolled cell proliferation. RB abnormalities are seen in a wide range of cancers, including breast, colon, prostate, kidney, nasopharyngeal tumors, and leukemias.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

Global: 48 Hrs, Tech-Only (stain only): 24 Hrs

CPT Codes

88360x1