Synonyms
Prostate Specific Membrane Antigen
Full Description
Identifies a 750 amino acid type II membrane glycoprotein with folate hydrolase and neuropeptidase activity expressed in normal and malignant prostatic epithelium and in a subset of non-prostatic tissues. In prostate cancer, PSMA expression correlates with disease progression, with the highest levels expressed in hormone-refractory and metastatic disease. Expression has also been reported on the neovasculature of a variety of non-prostatic solid tumors.
Methodology
IHC
Specimen Requirements
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 hrs
CPT Codes
88342 x 1 or 88341 x 1