IHC

Prostate Specific Antigen (PSA)

Identifies a glycoprotein localized to the cytoplasm of acinar and ductal epithelial cells of normal, benign, and malignant prostate tissue. It is a highly sensitive and specific marker for metastatic prostate adenocarcinoma. PSA produced by prostate cancer is immunologically and biochemically similar to that of normal prostate. Because it does not react with non-prostatic tumors, PSA is valuable for determining whether an isolated metastasis is of prostatic origin.

Synonyms

Prostate-Specific Antigen

Full Description

Identifies a glycoprotein localized to the cytoplasm of acinar and ductal epithelial cells of normal, benign, and malignant prostate tissue. It is a highly sensitive and specific marker for metastatic prostate adenocarcinoma. PSA produced by prostate cancer is immunologically and biochemically similar to that of normal prostate. Because it does not react with non-prostatic tumors, PSA is valuable for determining whether an isolated metastasis is of prostatic origin.

Methodology

IHC

Specimen Requirements

Preferred specimen: Formalin-fixed, paraffin-embedded (FFPE) tissue block Alternative specimen: Labeling Requirements:

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1