IHC

Prostate Specific Acid Phosphatase (PSAP)

Identifies a 100 kDa glycoprotein found in high concentration in prostate tissue and its secretions. It is specific for benign and malignant prostatic epithelial cells, with negative staining in prostatic stroma, urethra, and basal cells. PSAP expression may be lost in inflamed or infarcted tissue and in areas of squamous metaplasia. Nearly all metastatic prostatic carcinomas retain PSAP expression, making it a reliable marker for confirming prostatic origin.

Synonyms

PAPH

Full Description

Identifies a 100 kDa glycoprotein found in high concentration in prostate tissue and its secretions. It is specific for benign and malignant prostatic epithelial cells, with negative staining in prostatic stroma, urethra, and basal cells. PSAP expression may be lost in inflamed or infarcted tissue and in areas of squamous metaplasia. Nearly all metastatic prostatic carcinomas retain PSAP expression, making it a reliable marker for confirming prostatic origin.

Methodology

IHC

Specimen Requirements

Preferred specimen: Formalin-fixed, paraffin-embedded (FFPE) tissue block Alternative specimen: Labeling Requirements:

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1