IHC

PRAME (RED)

Preferentially expressed antigen in melanoma (PRAME) is detected in approximately 90% of melanoma subtypes and is negative in about 85% of cutaneous melanocytic nevi. This red-labeled immunostain is useful for supporting the diagnosis of melanoma by distinguishing malignant melanocytic lesions from benign nevi.

Full Description

Preferentially expressed antigen in melanoma (PRAME) is detected in approximately 90% of melanoma subtypes and is negative in about 85% of cutaneous melanocytic nevi. This red-labeled immunostain is useful for supporting the diagnosis of melanoma by distinguishing malignant melanocytic lesions from benign nevi.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1