IHC

Podoplanin (D240)

Identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Podoplanin is a marker of lymphatic endothelium, as well as neoplasms such as Kaposi's sarcoma. In the context of epithelial tumors, it has been demonstrated to be a highly sensitive marker of mesothelium and mesothelioma, complementing other markers such as calretinin and the Wilms tumor gene product. In neoplastic tissue, immunostaining of lymphatic endothelium can be useful in identifying lymphatic invasion of primary tumors.

Full Description

Identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Podoplanin is a marker of lymphatic endothelium, as well as neoplasms such as Kaposi's sarcoma. In the context of epithelial tumors, it has been demonstrated to be a highly sensitive marker of mesothelium and mesothelioma, complementing other markers such as calretinin and the Wilms tumor gene product. In neoplastic tissue, immunostaining of lymphatic endothelium can be useful in identifying lymphatic invasion of primary tumors.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1