IHC

PHOX2B

Identifies a nuclear transcription factor essential for the development of the autonomic nervous system. PHOX2B is a highly sensitive and specific marker for neuroblastoma, ganglioneuroblastoma, and ganglioneuroma, and is useful in distinguishing these tumors from other small round blue cell neoplasms.

Synonyms

Neuroblastoma

Full Description

Identifies a nuclear transcription factor essential for the development of the autonomic nervous system. PHOX2B is a highly sensitive and specific marker for neuroblastoma, ganglioneuroblastoma, and ganglioneuroma, and is useful in distinguishing these tumors from other small round blue cell neoplasms.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1