Synonyms
Phosphohistone H3
Full Description
Identifies a phosphorylated form of histone H3 associated with chromatin condensation during mitosis. PHH3 is a sensitive marker for highlighting mitotic figures and is widely used to assess tumor proliferative activity and improve accuracy in mitotic counting in various neoplasms.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1