Full Description
Identifies PAX8, a nuclear transcription factor essential in fetal development and involved in kidney and thyroid differentiation. PAX8 is expressed in major renal cell carcinoma subtypes (clear cell, chromophobe, papillary), as well as in ovarian, endometrial, and thyroid carcinomas. It shows exclusive nuclear staining and performs reliably in FFPE tissues.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1