IHC

P63

Identifies a homologue of the p53 gene that is essential for normal breast and prostate development. p63 is expressed in myoepithelial cells, squamous and transitional epithelial cells, and in the basal layer of prostate and other epithelial tissues. Unlike other myoepithelial and basal cell markers, p63 immunoreactivity is localized to the nucleus. Detection of p63, or its absence, is useful for identifying invasive carcinoma in breast and prostate, as well as for the diagnosis of squamous and transitional cell carcinomas.

Full Description

Identifies a homologue of the p53 gene that is essential for normal breast and prostate development. p63 is expressed in myoepithelial cells, squamous and transitional epithelial cells, and in the basal layer of prostate and other epithelial tissues. Unlike other myoepithelial and basal cell markers, p63 immunoreactivity is localized to the nucleus. Detection of p63, or its absence, is useful for identifying invasive carcinoma in breast and prostate, as well as for the diagnosis of squamous and transitional cell carcinomas.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1