IHC

p504s AMACR

Identifies a protein expressed in prostatic adenocarcinoma but absent in benign prostate tissue. It also stains premalignant lesions, including high-grade PIN and atypical adenomatous hyperplasia. This marker is positive in most prostate cancers and can also be expressed in other tumor types, such as hepatocellular carcinoma, breast carcinoma, pancreatic islet cell tumors, and desmoplastic small round cell tumors.

Synonyms

Alpha-Methylacyl-CoA Racemase

Full Description

Identifies a protein expressed in prostatic adenocarcinoma but absent in benign prostate tissue. It also stains premalignant lesions, including high-grade PIN and atypical adenomatous hyperplasia. This marker is positive in most prostate cancers and can also be expressed in other tumor types, such as hepatocellular carcinoma, breast carcinoma, pancreatic islet cell tumors, and desmoplastic small round cell tumors.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1