Full Description
Detects P120 Catenin, a tyrosine kinase that associates with E-cadherin at the cell membrane and is present in nearly all epithelial tissues. Loss of E-cadherin causes P120 Catenin to relocate to the cytoplasm, making this marker useful for distinguishing lobular (cytoplasmic staining) from ductal (membranous staining) breast neoplasms.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1