Full Description
Identifies the MUM1 gene product, a protein overexpressed in the late plasma-cell–directed stages of B-cell differentiation. It is positive in multiple myeloma, lymphoplasmacytic lymphoma, Reed-Sternberg cells of Hodgkin lymphoma, and about 50% of diffuse large B-cell lymphomas. It shows low expression in marginal zone, follicular, and CLL/SLL lymphomas, and is negative in Burkitt lymphoma. MUM1 expression is associated with poorer prognosis in diffuse large B-cell lymphoma.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1