IHC

MSH2

Identifies a mismatch repair protein involved in recognizing mismatched nucleotides during DNA replication. Loss of MSH2 expression leads to genomic instability and is associated with Lynch Syndrome–related tumors, as well as sporadic colorectal and other carcinomas with microsatellite instability (MSI).

Full Description

Identifies a mismatch repair protein involved in recognizing mismatched nucleotides during DNA replication. Loss of MSH2 expression leads to genomic instability and is associated with Lynch Syndrome–related tumors, as well as sporadic colorectal and other carcinomas with microsatellite instability (MSI).

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE )tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

Global: 48 Hrs, Tech-Only (stain only): 24 Hrs

CPT Codes

88342x1 or 88341x1 ; 88360x1 or 88361x1