Full Description
Detects a mismatch repair protein essential for maintaining genomic stability. Mutations or loss of MLH1 expression are associated with microsatellite instability (MSI) and are seen in certain colonic, endometrial, gastric, ovarian, and breast carcinomas, as well as in some cases of acute lymphoblastic leukemia.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
Global: 48 hours, Image Analysis (tech-only): 36 hours, Tech-Only (stain only): 24 hours
CPT Codes
88342x1 or 88341x1; 88360x1 or 88361x1