IHC

Melan Cocktail (Mart 1/S100/Tyrosinase)

Identifies a copper-containing metalloglycoprotein that serves as the rate-limiting enzyme in melanin synthesis. It is a marker of melanocytic cells and tumors and a target for cytotoxic T-cell recognition in melanoma. This antibody stains both melanotic and amelanotic melanomas, though it is generally less sensitive than HMB-45 and MART-1.

Full Description

Identifies a copper-containing metalloglycoprotein that serves as the rate-limiting enzyme in melanin synthesis. It is a marker of melanocytic cells and tumors and a target for cytotoxic T-cell recognition in melanoma. This antibody stains both melanotic and amelanotic melanomas, though it is generally less sensitive than HMB-45 and MART-1.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1