IHC

Mart 1

Identifies a differentiation antigen expressed in melanocytes and serves as a sensitive and specific marker for melanoma. It recognizes a subcellular fraction found in melanosomes and is valuable in melanoma panels due to its specificity for melanocytic lesions. Melan A is typically co-expressed with HMB-45 in most melanomas but is also expressed in sex cord-stromal and adrenal cortical tumors, making it useful in distinguishing these neoplasms.

Synonyms

Melan A

Full Description

Identifies a differentiation antigen expressed in melanocytes and serves as a sensitive and specific marker for melanoma. It recognizes a subcellular fraction found in melanosomes and is valuable in melanoma panels due to its specificity for melanocytic lesions. Melan A is typically co-expressed with HMB-45 in most melanomas but is also expressed in sex cord-stromal and adrenal cortical tumors, making it useful in distinguishing these neoplasms.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1