IHC

Mammaglobin

Identifies a breast-associated glycoprotein that is a sensitive and specific marker of carcinomas primary to the breast. In normal breast tissue, this antibody labels breast ductal and lobular epithelial cells; in tumor cells, it reacts with all types of breast adenocarcinoma regardless of tumor differentiation and type. This protein can also be expressed in a subset of salivary gland tumors as well as ovarian carcinomas, but adenocarinomas from other organs rarely express mammaglobin. It can help in the identification of primary cites of carcinomas.

Full Description

Identifies a breast-associated glycoprotein that is a sensitive and specific marker of carcinomas primary to the breast. In normal breast tissue, this antibody labels breast ductal and lobular epithelial cells; in tumor cells, it reacts with all types of breast adenocarcinoma regardless of tumor differentiation and type. This protein can also be expressed in a subset of salivary gland tumors as well as ovarian carcinomas, but adenocarinomas from other organs rarely express mammaglobin. It can help in the identification of primary cites of carcinomas.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1