Synonyms
Lymphoid Enhancer-binding Factor 1
Full Description
Identifies a nuclear transcription factor involved in the WNT/β-catenin signaling pathway, normally expressed in T cells and immature pro-B cells. LEF1 is highly expressed in CLL/SLL and is useful for distinguishing it from other small B-cell lymphomas such as mantle cell, marginal zone, and follicular lymphoma.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE )tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1