Full Description
Identifies a type II transmembrane protein expressed in Langerhans cells. It is involved in the formation of Birbeck granules and antigen processing. Langerin is a useful marker for diagnosing Langerhans cell histiocytosis and distinguishing Langerhans cells from other dendritic or histiocytic cell populations.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1