Full Description
Identifies a nuclear protein expressed in actively dividing cells (late G1, S, G2, and M phases) but absent in resting (G0) cells. It serves as a marker of cell proliferation, helping assess tumor growth rate and prognosis, with higher Ki-67 expression indicating more aggressive disease.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
Global: 48 Hrs, Image Analysis (tech-only): 36 Hrs, Tech-Only (stain only): 24 Hrs
CPT Codes
88342x1 or 88341x1 (qualitative IHC) or 88360 (quantitative/semi-quantitative – manual) or 88361x1 (quantitative/semi-quantitative – computer assisted)