IHC

Keratin CAM5.2

Recognizes low molecular weight cytokeratins (CK8 and CK18) found in most simple epithelia and their derived carcinomas. It is useful for identifying epithelial origin in poorly differentiated tumors and is typically positive in adenocarcinomas of the lung, breast, and gastrointestinal tract, while negative in most sarcomas, lymphomas, and melanomas.

Synonyms

Cytokeratin LMW

Full Description

Recognizes low molecular weight cytokeratins (CK8 and CK18) found in most simple epithelia and their derived carcinomas. It is useful for identifying epithelial origin in poorly differentiated tumors and is typically positive in adenocarcinomas of the lung, breast, and gastrointestinal tract, while negative in most sarcomas, lymphomas, and melanomas.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1