IHC

Kappa Light Chains

Identifies Kappa and lambda immunoglobulin light chains, which are expressed by plasma cells and plasmacytoid lymphocytes, and less reliably detected on B cells with small amounts of cytoplasm. This antibody is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin lymphomas. Demonstration of monotypism in lymphoid infiltrates is a surrogate for clonality, and therefore malignancy.

Full Description

Identifies Kappa and lambda immunoglobulin light chains, which are expressed by plasma cells and plasmacytoid lymphocytes, and less reliably detected on B cells with small amounts of cytoplasm. This antibody is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin lymphomas. Demonstration of monotypism in lymphoid infiltrates is a surrogate for clonality, and therefore malignancy.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1