IHC

INI-1 SMARCB1

Identifies the gene product of the INI-1 gene, a tumor suppressor gene, and inactivation through mutation or other mechanism characterizes a unique subset of tumors that includes renal and extrarenal rhabdoid tumors, atypical teratoid/rhabdoid tumors of the central nervous system, distal and proximal variants of epithelioid sarcoma, as well as a subset of mesenchymal chondrosarcomas, epithelioid malignant peripheral nerve sheath tumors, and soft tissue myoepitheliomas. A lack of nuclear expression of INI1 is characteristic of malignant rhabdoid tumors and epithelioid sarcomas.

Synonyms

SMARCB1, hSNF5, BAF47

Full Description

Identifies the gene product of the INI-1 gene, a tumor suppressor gene, and inactivation through mutation or other mechanism characterizes a unique subset of tumors that includes renal and extrarenal rhabdoid tumors, atypical teratoid/rhabdoid tumors of the central nervous system, distal and proximal variants of epithelioid sarcoma, as well as a subset of mesenchymal chondrosarcomas, epithelioid malignant peripheral nerve sheath tumors, and soft tissue myoepitheliomas. A lack of nuclear expression of INI1 is characteristic of malignant rhabdoid tumors and epithelioid sarcomas.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1