IHC

IgD = Immunoglobulin D

This antibody reacts with immunoglobulin Ig delta chains, cytoplasmic proteins strongly expressed by naive/mantle zone B-cells and a small subset of plasma cells, and weakly expressed by germinal center B cells. This antibody is useful in identifying leukemias, plasmacytomas, and B-cell lineage lymphomas, as well as a subset of B-cell non-Hodgkin lymphomas and normal mantle zone B-lymphocytes.

Synonyms

Kappa-Heavy Chain

Full Description

This antibody reacts with immunoglobulin Ig delta chains, cytoplasmic proteins strongly expressed by naive/mantle zone B-cells and a small subset of plasma cells, and weakly expressed by germinal center B cells. This antibody is useful in identifying leukemias, plasmacytomas, and B-cell lineage lymphomas, as well as a subset of B-cell non-Hodgkin lymphomas and normal mantle zone B-lymphocytes.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1