IHC

HHV8

Identifies a nuclear protein expressed by cells infected with Human Herpes Virus 8, which is expressed in both Kaposi's sarcoma and HHV8-associated lymphoproliferative disorders, including primary effusion lymphomas and multicentric Castleman's disease. HHV8 encodes a latent nuclear antigen (LANA) that is the product of the viral gene 73.

Synonyms

Human Herpes Virus 8

Full Description

Identifies a nuclear protein expressed by cells infected with Human Herpes Virus 8, which is expressed in both Kaposi's sarcoma and HHV8-associated lymphoproliferative disorders, including primary effusion lymphomas and multicentric Castleman's disease. HHV8 encodes a latent nuclear antigen (LANA) that is the product of the viral gene 73.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.

Turnaround Time

Global: 48 Hrs, Tech-Only (stain only): 24 Hrs

CPT Codes

88342x1 or 88341x1