Synonyms
Human Epidermal Growth Factor Receptor 2
Full Description
A transmembrane tyrosine kinase receptor in the EGFR family, HER2 is overexpressed or amplified in various tumors, including breast and gastric cancers. HER2 status serves as both a prognostic and predictive marker and guides therapy with trastuzumab and other HER2-targeted agents.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
Global: 48 Hrs, Tech-Only (stain only): 24 Hrs
CPT Codes
88360 x1