IHC

Granzyme B

A cytotoxic protein expressed in cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Granzyme B is useful for identifying tumors of CTL or NK-cell origin and for differentiating them from other hematolymphoid neoplasms. It is commonly used in the evaluation of anaplastic large cell lymphoma, large granular lymphocytic leukemia, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, NK-like T-cell lymphoma, NK-cell lymphoma, nasal T/NK-cell lymphoma, and subcutaneous panniculitic T-cell lymphoma.

Full Description

A cytotoxic protein expressed in cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Granzyme B is useful for identifying tumors of CTL or NK-cell origin and for differentiating them from other hematolymphoid neoplasms. It is commonly used in the evaluation of anaplastic large cell lymphoma, large granular lymphocytic leukemia, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, NK-like T-cell lymphoma, NK-cell lymphoma, nasal T/NK-cell lymphoma, and subcutaneous panniculitic T-cell lymphoma.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1