Full Description
A cytoplasmic enzyme that catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine synthetase is expressed in hepatocytes, particularly around the central veins, and is a useful marker for identifying hepatocellular lesions, including hepatocellular carcinoma, and for assessing liver zonation and metabolic patterns.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1