Full Description
A cytoplasmic adaptor protein involved in signal transduction from receptor tyrosine kinases, including MET and EGFR. Gab1 plays a role in cell growth, differentiation, and survival. Immunohistochemical detection of Gab1 can aid in studying tumors with dysregulated MET or EGFR signaling pathways, including certain carcinomas and sarcomas.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1