Full Description
A highly conserved actin-bundling protein expressed mainly in dendritic cells. Fascin is negative in most lymphoid, myeloid, and plasma cells, but positive in Reed-Sternberg cells of Hodgkin lymphoma, helping to distinguish it from anaplastic large cell lymphoma. EBV infection may induce fascin expression in B-cells.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1