Full Description
ERG is a member of the ETS transcription factor gene family and is strongly overexpressed in endothelial cells and is a highly specific and sensitive marker of vascular neoplasms, and expression has been shown to be a highly specific marker for prostate cancer. ERG expression is lacking in a wide variety of normal epithelial tissues and tumors, therefore detection of ERG by IHC is a useful tool for diagnosing prostate cancer or determining prostatic origin.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1