Full Description
This antibody cocktail is used to distinguish luminal (ER-positive) from basal-like (CK5-positive) breast carcinomas. Estrogen receptor (ER) identifies hormone-responsive luminal epithelial cells, while cytokeratin 5 (CK5) highlights basal/myoepithelial cells. The combined stain aids in subtyping breast cancers for prognosis and treatment planning, as well as differentiating benign proliferations from malignant lesions.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1