IHC

EBV/LMP

Identifies EBV latent membrane protein-1, a cell surface-associated protein encoded by the EBV genome and expressed by a subset of EBV-infected B-cells. It shows strong reactivity in EBV-positive lymphoblastoid cell lines, EBV-infected immunoblasts in infectious mononucleosis, and certain EBV-associated neoplasms such as Hodgkin lymphoma. LMP-1 is a less sensitive marker compared to EBER for detecting EBV infection.

Synonyms

Epstein-Barr Virus/Latent Membrane Protein 1

Full Description

Identifies EBV latent membrane protein-1, a cell surface-associated protein encoded by the EBV genome and expressed by a subset of EBV-infected B-cells. It shows strong reactivity in EBV-positive lymphoblastoid cell lines, EBV-infected immunoblasts in infectious mononucleosis, and certain EBV-associated neoplasms such as Hodgkin lymphoma. LMP-1 is a less sensitive marker compared to EBER for detecting EBV infection.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1