Synonyms
Epstein-Barr Virus by ISH
Full Description
Detects Epstein-Barr virus–encoded RNA within infected cells, identifying all latent EBV-infected cells, including EBV-positive lymphoblastoid cell lines and B-cell immunoblasts in infectious mononucleosis. It is also positive in EBV-associated undifferentiated nasopharyngeal carcinomas and Reed-Sternberg cells in nearly all EBV-associated Hodgkin lymphoma cases.
Methodology
ISH
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
Global (head and neck only): 72 Hrs, Tech-Only (stain only): 48 Hrs
CPT Codes
88365x1 or 88364x1