IHC

ECAD

Identifies a transmembrane cell-cell adhesion protein that is expressed in epithelial cells. It stains positively in glandular epithelium and in adenocarcinomas of the lung, gastrointestinal tract, and ovary. E-cadherin is useful in distinguishing adenocarcinoma from mesothelioma, and in differentiating lobular carcinoma (which shows loss or marked reduction of expression) from ductal carcinoma of the breast.

Synonyms

E-Cadherin

Full Description

Identifies a transmembrane cell-cell adhesion protein that is expressed in epithelial cells. It stains positively in glandular epithelium and in adenocarcinomas of the lung, gastrointestinal tract, and ovary. E-cadherin is useful in distinguishing adenocarcinoma from mesothelioma, and in differentiating lobular carcinoma (which shows loss or marked reduction of expression) from ductal carcinoma of the breast.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1