Full Description
Identifies a cell surface protein selectively expressed in gastrointestinal stromal tumors (GIST) and complements other markers such as c-Kit (CD117). It detects most c-Kit–negative and PDGFRA-mutated GISTs that may still respond to imatinib therapy. DOG1 shows fewer cross-reactions with mesenchymal, epithelial tumors, and melanomas, improving GIST diagnostic accuracy.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1